Information and Communication Technology in Education is vital in the 21st-century classroom, enabling digital literacy, flexible learning and access to a wealth of online educational resources. This study investigate the influence of Information and Communication Technology ICT in teaching and learning of Mathematics in secondary school in Oyo West Local Government Area, Oyo, Oyo State. Two different questionnaire was employed 1 for the Teachers and 1 for the Students to a sample 110, 10 Teachers and 100 Students from 5 secondary schools in Oyo West Local Government Area, Oyo, Oyo State. The instrument was validated by the two experts. Hypothesis were tested at 0.05 level of significant. Chi-square statistic was used to analyze the data collected. The results shows a significant positive correlation between the influence of Information and Communication Technology ICT in teaching of Mathematics and influence of Information and Communication Technology ICT in learning of Mathematics. There is a significant relationship on ICT usage and students' understanding of Mathematics concept and Mathematics teaching methods in secondary schools within Oyo West Local Government Area, Oyo, Oyo State. There is a significant relationship on possibly teachers’ related factors and ICT integration challenges in secondary schools within Oyo West Local Government Area, Oyo, Oyo State. The study concludes that teaching and learning of Mathematics is influenced by Information and Communication Technology. The study recommend that effective integration of ICT in the teaching and learning of Mathematics requires adequate infrastructure